Palavicini Lab Publications

The Palavicini lab in collaboration with multiple laboratories at UT Health SA and external institutions, frequently publishes their findings in scientific journals. Below you can find a list of our most recent peer-reviewed papers, preprints, and manuscripts under revision.

Recent peer-reviewed publications (since 2023)

Science Advances, 2024. Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease

iScience, 2024. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice

Nature Medicine, 2023. Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial

Clinical and Translational Medicine, 2023. Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer’s disease

Glia. 2023. Adult-onset depletion of sulfatide leads to axonal degeneration with relative myelin sparing

Biomedicines. 2023. Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion

Neural Regeneration Research, 2023. Myelin lipid deficiency: a new key driver of Alzheimer's disease

In Press/Preprints

Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease

Garbarino VR, Palavicini JP, Melendez J, Barthelemy N, He Y, Kautz TF, Lopez-Cruzan M, Mathews JJ, Xu P, Zhang B, Saliba A, Ragi N, Sharma K, Craft S, Petersen RC, Espindola J, Netto M, Xue A, Tchkonia T, Kirkland JL, Seshadri S, Salardini A, Musi N, Bateman RJ, Gonzalez MM, Orr ME.

Research Square, 2024.

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Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain

Sarah C. Hopp*, Juliet Garcia Rogers, Sabrina Smith, Gabriela Campos, Henry Miller, Savannah Barannikov, Eduardo Gutierrez Kuri, Hu Wang, Xianlin Han, Kevin F. Bieniek, Susan T. Weintraub, Juan Pablo Palavicini*

bioRxiv, 2023.

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Persistent Inflammatory Lipotoxicity Impedes Pancreatic β-cell Function in Diet-Induced Obese Mice Despite Correction of Glucotoxicity

Ivan A. Valdez, Juan Pablo Palavicini, Terry M. Bakewell, Marcel Fourcaudot, Iriscilla Ayala, Ziying Xu, Ahmed Khattab, Xianlin Han, Chris E. Shannon, Luke Norton

bioRxiv, 2022

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Manuscripts under review

Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain including myelin homeostasis and fatty acid oxidation

Sarah C. Hopp, Juliet Lynn Marie Garcia Rogers, Eduardo Gutierrez Kuri, Sabrina Smith, Gabriela Campos, Henry Miller, Savannah Barannikov, Hu Wang, Sammy Pardo, Xianlin Han, Kevin F. Bieniek, Susan T. Weintraub, Juan Pablo Palavicini.

Under review at Molecular Neurodegeneration

Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer’s Disease

Garbarino VR, Palavicini JP, Melendez J, Barthelemy N, He Y, Kautz TF, Lopez-Cruzan M, Mathews JJ, Xu P, Zhang B, Saliba A, Ragi N, Sharma K, Craft S, Petersen RC, Espindola J, Netto M, Xue A, Tchkonia T, Kirkland JL, Seshadri S, Salardini A, Musi N, Bateman RJ, Gonzalez MM, Orr ME.

Under review at Nature Aging