Our Research

The overarching goal of the Palavicini lab is to better understand how gene-environment interactions influence Alzheimer’s disease (AD) and aging, with a particular focus on genes involved in lipid metabolism that have been linked to AD and/or longevity.

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The lab performs mechanistic pre-clinical studies on animal models using multi-faceted approaches to generate multi-omics, histological, imaging, physiological, and behavioral outcomes in a rigorous manner, following robust, well-powered, reproducible, and unbiased experimental designs.

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Validating the clinical relevance of basic discoveries in human samples is a critical component of the laboratory, as ultimately, we aim to develop translational strategies to combat age-related metabolic dysfunction and cognitive decline. To this end, we partner with ongoing clinical trials to assess the effects that specific treatments against aging and/or Alzheimer's disease may have on lipid metabolism.