WELCOME
The Palavicini Lab seeks to better understand the molecular mechanisms that drive Alzheimer's disease and aging, with a particular focus on lipid signaling and gene-environment interactions.
Our ultimate goal is to participate in the development of new therapies that will empower us to live a sharper, healthier, and longer life!
Our Research
The overarching goal of the Palavicini lab is to better understand how gene-environment interactions influence Alzheimer’s disease (AD) and aging, with a particular focus on genes involved in lipid metabolism that have been linked to AD and/or longevity.
The lab performs mechanistic pre-clinical studies on animal models using multi-faceted approaches to generate multi-omics, histological, imaging, physiological, and behavioral outcomes in a rigorous manner, following robust, well-powered, reproducible, and unbiased experimental designs.
Validating the clinical relevance of basic discoveries in human samples is a critical component of the laboratory, as ultimately, we aim to develop translational strategies to combat age-related metabolic dysfunction and cognitive decline. To this end, we partner with ongoing clinical trials to assess the effects that specific treatments against aging and/or Alzheimer's disease may have on lipid metabolism.
